反应 #172475

反应方程式

water

3-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]-5,5-dimethyl-2-cyclohexenone

sodium hydride

diethyl cyanomethylphosphonate

→

[3-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]-5,5-dimethyl-2-cyclohexenylidene]acetonitrile

收率 82.0%

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

后处理

1. 1
   萃取extraction with ethyl acetate
2. 2
   洗涤The extract was washed with a saturated saline solution
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   浓缩concentrated
5. 5
   其他The residue was purified by silica gel column chromatography
6. 6
   其他to give 1.05 g of an orange oily matter (yield: 82.0%)

实验过程

To 0.23 g (9.6 mmol) of sodium hydride, 20 ml of tetrahydrofuran was added. To this mixture, 1.39 g (7.85 mmol) of diethyl cyanomethylphosphonate was added dropwise under ice cooling. To the mixture, 1.21 g (3.15 mmol) of 3-[2-(4-dibutylamino-2-methoxyphenyl)vinyl]-5,5-dimethyl-2-cyclohexenone in tetrahydrofuran was added dropwise. After the reaction mixture was stirred at 50° C. overnight, water was added thereto and extraction with ethyl acetate was performed. The extract was washed with a saturated saline solution, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel column chromatography to give 1.05 g of an orange oily matter (yield: 82.0%).

来源