反应 #171240

反应方程式

3,7,11,15-Tetramethyl-hexadecan-1-ol

sodium disulfite

chromic acid

→

title compound

收率 72.3%

3,7,11,15-tetramethyl-1-hexadecanoic acid

收率 72.3%

溶剂

acetone

acetic acid

water

water

反应条件

后处理

1. 1
   其他after completion of the reaction
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature overnight
3. 3
   萃取extracted 6 times with diethyl ether (135 ml)
4. 4
   其他The solvent of the obtained organic layer was evaporated under reduced pressure
5. 5
   workup.ADDITIONDiethylether (450 ml) and water (150 ml) were added to the oil
6. 6
   浓缩after concentration
7. 7
   其他to allow partitioning
8. 8
   萃取the aqueous layer was extracted 3 times with ethyl acetate (150 ml)
9. 9
   干燥The combined organic layer was dried over anhydrous sodium sulfate
10. 10
    其他the solvent was evaporated under reduced pressure
11. 11
    浓缩The oil (10.1 g) after concentration
12. 12
    其他was purified by chromatography (silica gel; 250 g, eluate; 50:1→3:1 hexane-ethyl acetate)

实验过程

3,7,11,15-Tetramethyl-hexadecan-1-ol (8.96 g, 30.0 mmol) was dissolved in a mixed solvent of acetone (360 ml) and acetic acid (180 ml), a solution of anhydrous chromic acid (7.27 g, 72.7 mmol) in water (9.0 ml) was added dropwise, and the mixture was stirred at room temperature for 1 hr. A solution of sodium disulfite (100 g, 526 mmol) in water (450 ml) was added to the reaction mixture after completion of the reaction, the mixture was stirred at room temperature overnight and extracted 6 times with diethyl ether (135 ml). The solvent of the obtained organic layer was evaporated under reduced pressure. Diethylether (450 ml) and water (150 ml) were added to the oil after concentration to allow partitioning, and the aqueous layer was extracted 3 times with ethyl acetate (150 ml). The combined organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The oil (10.1 g) after concentration was purified by chromatography (silica gel; 250 g, eluate; 50:1→3:1 hexane-ethyl acetate) to give the title compound (6.78 g, 72.3%) as a pale-blue oil.

来源