反应 #170491

反应方程式

6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-ylamine

methyloxalylchloride

→

title compound

收率 60.0%

N-[6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-oxalamic acid methyl ester

收率 60.0%

反应条件

实验过程

As described for example 179b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-ylamine (150 mg, 0.53 mmol) was converted, using methyloxalylchloride instead of acetyl chloride, to the title compound (118 mg, 60%) which was obtained as a white solid after purification by chromatography (SiO2, dichloromethane:methanol=100:0 to 9:1). MS: m/e=368.0 [M+H]+.

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