反应 #170241
ord-99f898b4185b45aaabdee714fe8b2e5d
反应方程式
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1萃取extracted with dichloromethane (3×50 mL)
- 2干燥The combined organic layers were dried over sodium sulfate
- 3过滤filtered
- 4浓缩concentrated to dryness
实验过程
To a solution of 1-benzhydryl-3-(benzofuran-3-yl)azetidin-3-ol (760 mg, 2.14 mmol) in dichloromethane (10 mL) was added at 0° C. triethylamine (387 μL, 2.78 mmol) and then dropwise a solution of methanesulfonyl chloride (216 μL, 2.78 mmol) in dichloromethane (3 mL). The reaction mixture was stirred for 1 hour at room temperature, then diluted with water (50 mL) and extracted with dichloromethane (3×50 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated to dryness. The crude title compound was obtained as a yellow gum (873 mg, 109%) and used for the next step without further purification.