反应 #1702092

反应方程式

CBzCl

HCl

(2-amino-ethyl)-phosphonic acid diethyl ester

iPr2NEt

→

(2-benzyloxycarbonylamino-ethyl)-phosphonic acid diethyl ester

溶剂

EtOAc

CH2Cl2

反应条件

后处理

1. 1
   其他The reaction was quenched by the addition of saturated NaHCO3
2. 2
   其他The mixture was then partitioned between CH2Cl2 and H2O
3. 3
   其他The layers were separated
4. 4
   洗涤the organic layer was washed with brine
5. 5
   干燥dried over Na2SO4
6. 6
   其他The drying agent was removed by vacuum filtration

实验过程

The HCl salt of (2-amino-ethyl)-phosphonic acid diethyl ester (4.5 g, 20.7 mmol) was dissolved in CH2Cl2 (100 mL). To this solution was added CBzCl (3.2 mL, 22.7 mmol), followed by iPr2NEt (14.4 mL, 82.8 mmol). The reaction was stirred at room temperature until complete, as determined by TLC (eluent: 100% EtOAc). The reaction was quenched by the addition of saturated NaHCO3. The mixture was then partitioned between CH2Cl2 and H2O. The layers were separated and the organic layer was washed with brine and then dried over Na2SO4. The drying agent was removed by vacuum filtration and (2-benzyloxycarbonylamino-ethyl)-phosphonic acid diethyl ester was isolated from the concentrated filtrate by silica gel column chromatography (EtOAc/hexanes) (5.98 g, 92%).

来源