反应 #1702080

反应方程式

dichloromethane

acetone

5-cyclopropyl-1-(2-(4-fluorophenyl)-2-oxoethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

sodium borohydride

→

desired product

收率 46.0%

5-cyclopropyl-1-(2-(4-fluorophenyl)-2-hydroxyethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

收率 46.0%

溶剂

ethanol

反应条件

后处理

1. 1
   洗涤The resulting solution was washed with water
2. 2
   干燥the organic phase was dried over sodium sulfate
3. 3
   过滤filtered
4. 4
   其他Evaporation

实验过程

To a solution of 5-cyclopropyl-1-(2-(4-fluorophenyl)-2-oxoethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one (65.0 mg, 0.170 mmol) from Example 5 in ethanol (1 ml) was added sodium borohydride (6.4 mg, 0.170 mmol) and the reaction mixture was stirred at room temperature over weekend. Then was added acetone (0.062 ml) followed by dilution with dichloromethane. The resulting solution was washed with water and the organic phase was dried over sodium sulfate and filtered. Evaporation gave the desired product (30 mg, 46%).

来源