反应 #1702077

反应方程式

diethylether

2-(4-chlorophenyl)ethanol

Dess-Martin periodinane

→

desired compound

收率 42.2%

2-(4-chlorophenyl)acetaldehyde

收率 42.2%

溶剂

dichloromethane

反应条件

后处理

1. 1
   洗涤the resulting mixture was washed with a 1:1 solution (150 ml) of sodium carbonate (aqueous saturated) and sodium thiosulfate (aqueous saturated)
2. 2
   干燥The organic phase was then dried over sodium sulfate
3. 3
   其他evaporated

实验过程

To a solution of 2-(4-chlorophenyl)ethanol (2.00 g, 12.77 mmol) in dichloromethane (100 ml) was added Dess-Martin periodinane (8.12 g, 19.16 mmol) and the mixture was stirred at room temperature over weekend. Then was added diethylether (150 ml) and the resulting mixture was washed with a 1:1 solution (150 ml) of sodium carbonate (aqueous saturated) and sodium thiosulfate (aqueous saturated) and then with sodium bicarbonate (aqueous saturated) and finally with brine. The organic phase was then dried over sodium sulfate and evaporated. Silica gel flash chromatography (pentan/ethylacetate:9/1) afforded the desired compound (0.834 g, 42%) as a white solid.

来源