反应 #1702073
ord-a8b5dcdd27e04124891270579f140223
反应方程式
反应物
试剂
反应条件
后处理
- 1萃取extracted by ethyl acetate
- 2洗涤The organic layer was washed by water
- 3干燥a saturated sodium hydrogen carbonate aq. solution and a saturated saline solution, dried over magnesium sulfate
- 4浓缩concentrated under reduced pressure
- 5其他The crude product was purified by silica gel chromatography
实验过程
The synthesis process is as set forth in the chemical reaction formula below. The CAN in the reaction path stands for cerium ammonium nitrate. To 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-methylnaphthalene (b) (202 mg, 1.00 mol) were added acetic acid (8.2 mL) and cerium ammonium nitrate (2.40 g, 4.37 mol) followed by stirring at 100° C. for 1 hour. The reaction solution was poured into ice water and extracted by ethyl acetate. The organic layer was washed by water, a saturated sodium hydrogen carbonate aq. solution and a saturated saline solution, dried over magnesium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography using hexane/ethyl acetate (15/1) as an elution solvent. The yield was 106 mg (49%).