反应 #1702028

ord-18e93aaaba5442d19bf07955f73473f8

反应方程式

O=P([O-])([O-])[O-]
phosphate
CC(=O)O.N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
desmopressin acetate
→
N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
Desmopressin

反应物

O=P([O-])([O-])[O-]
phosphate
CC(=O)O.N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
desmopressin acetate

试剂

无

溶剂

Cl
Hydrochloric acid

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    workup.DISSOLUTIONDissolution tests of pellets
  2. 2
    其他have been carried out according to USP apparatus 2 at 37° C.

实验过程

Dissolution tests of pellets have been carried out according to USP apparatus 2 at 37° C., paddle speed 100 rpm, phosphate buffer pH 6.0, n=6, 1 g per vessel according to about 1400-2100 μg desmopressin acetate. Additionally the enteric pellets were treated 2 h in Hydrochloric acid, 0.1N, before switching at pH 6.0.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08765152B2uspto-grants-2014_07