反应 #1700421

反应方程式

methoxythioacetamide

2-chloro-1-(4-nitrophenyl)hexan-3-one

charcoal

→

2-methoxymethyl-4-propyl-5-(4-nitrobenzyl)thiazole

收率 25.7%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   温度is heated at 90°-100° C. for 4 hours
2. 2
   温度cooled
3. 3
   其他The solution obtained
4. 4
   其他evaporated
5. 5
   其他The brown oil obtained
6. 6
   其他is purified on a silica column (eluent: 6/4 cyclohexane/ethyl acetate)

实验过程

A mixture of 1.2 g of methoxythioacetamide and 3 g of 2-chloro-1-(4-nitrophenyl)hexan-3-one is heated at 90°-100° C. for 4 hours and then cooled and taken up with ethyl acetate. The solution obtained is passed over animal charcoal and then evaporated. The brown oil obtained is purified on a silica column (eluent: 6/4 cyclohexane/ethyl acetate) to give 0.9 g of 2-methoxymethyl-4-propyl-5-(4-nitrobenzyl)thiazole in the form of a brown oil, which is used as such for the next step.

来源