反应 #169674

反应方程式

Amino-acetic acid 4-allyl-2-methoxy-phenyl ester

niacin

N-methyl morpholine

EDC.HCl

→

product

收率 43.0%

[(pyridine-3-carbonyl)-amino]-acetic acid 4-allyl-2-methoxy-phenyl ester

收率 43.0%

溶剂

DCM

DCM

反应条件

后处理

1. 1
   洗涤washed with water (2×100 mL)
2. 2
   干燥dried over sodium sulphate
3. 3
   其他The crude product obtained upon evaporation of the solvent
4. 4
   其他was purified by silica gel column chromatography

实验过程

To a solution of Amino-acetic acid 4-allyl-2-methoxy-phenyl ester (510 mg, 1.7 mmol), in DCM (20 mL) were added niacin (0.23 g, 1.9 mmol), N-methyl morpholine (0.96 mL, 8.8 mmol), EDC.HCl (0.67 g, 3.5 mmol) at ice temperature (0° C.). The mixture was allowed to stir at room temperature (25° C.) over a period of 2 hrs. The resulting mixture was diluted with DCM (200 mL) washed with water (2×100 mL) and dried over sodium sulphate. The crude product obtained upon evaporation of the solvent was purified by silica gel column chromatography to obtain product as off-white solid (210 mg, 43%).

来源