反应 #169520

反应方程式

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid

SOCl2

→

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonyl chloride

溶剂

toluene

反应条件

后处理

1. 1
   workup.DISTILLATIONThe toluene and SOCl2 are distilled from the reaction mixture after 30 minutes
2. 2
   workup.ADDITIONAdditional toluene (2.5 vol) is added
3. 3
   workup.DISTILLATIONdistilled again

实验过程

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid (1.2 eq) is slurried in toluene (2.5 vol) and the mixture heated to 60° C. SOCl2 (1.4 eq) is added via addition funnel. The toluene and SOCl2 are distilled from the reaction mixture after 30 minutes. Additional toluene (2.5 vol) is added and distilled again.

来源