反应 #1692549

反应方程式

methyl isothiocyanate

ethylenediamine

5-benzyl-4-chloromethyloxazole

N-(5-benzyl-4-oxazolylmethyl)ethylenediamine

→

N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]-thiourea

反应条件

实验过程

Reacting ethylenediamine with 5-benzyl-4-chloromethyloxazole by the procedure of Example 34, then reacting the resulting N-(5-benzyl-4-oxazolylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) and chromatographing gives N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]-thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3(b) gives N-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]-N'-cyano-N"-methylguanidine.

来源