反应 #1689

反应方程式

HCl

phenethylamine

triethylamine

methyl chloroformate

→

title compound

收率 95.0%

N-Methoxycarbonylphenethylamine

收率 95.0%

溶剂

diethyl ether

THF

THF

反应条件

后处理

1. 1
   洗涤The organic layer was washed with water
2. 2
   干燥dried (MgSO4)
3. 3
   过滤filtered
4. 4
   浓缩the filtrate was concentrated in vacuo

实验过程

To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).

来源