反应 #168830

反应方程式

Hydrogen peroxide water

tetrahydrofuran

2-fluoro-3-methylpyridine-5-boronic acid

→

6-fluoro-5-methylpyridin-3-ol

收率 96.0%

溶剂

Water

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   洗涤The organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   浓缩concentrated under reduced pressure

实验过程

Hydrogen peroxide water (4.37 ml, 42.8 mmol) was added to a tetrahydrofuran solution (50 ml) of 2-fluoro-3-methylpyridine-5-boronic acid (5.1 g, 32.9 mmol), and stirred overnight at room temperature. Water was added to the reaction solution, and extracted with ethyl acetate. The organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 6-fluoro-5-methylpyridin-3-ol (4.03 g, yield: 96%) as a pale yellow solid.

来源