反应 #1687668

反应方程式

benzyl 2,4-dihydroxybenzoate

potassium carbonate

methyallyl chloride

→

benzyl 2-hydroxy-4-(2-methylallyloxy)benzoate

收率 57.5%

溶剂

DMF

反应条件

后处理

1. 1
   其他brought to 70° C.
2. 2
   过滤the salts are filtered off
3. 3
   洗涤The salts were washed with DMF
4. 4
   其他the solvent was evaporated off
5. 5
   其他A brown oil was obtained which
6. 6
   其他was purified on silica (eluent: 70/30 heptane/CH2Cl2)

实验过程

To a mixture of 17 g of benzyl 2,4-dihydroxybenzoate (0.07 mol) and 10 g of potassium carbonate (0.077 mol) in 60 ml of DMF brought to 70° C. were added 6.81 ml of methyallyl chloride (0.07 mol) dropwise over 1 hour. The mixture was left at 70° C. for 2 hours. It is cooled to about 40° C. and the salts are filtered off. The salts were washed with DMF. The liquids were combined, and the solvent was evaporated off. A brown oil was obtained which was purified on silica (eluent: 70/30 heptane/CH2Cl2). The head fractions were pooled to give 12 g (yield: 57%) of benzyl 2-hydroxy-4-(2-methylallyloxy)benzoate in the form of a colourless oil.

来源