反应 #1687653

反应方程式

hydrogen chloride

p-xylene

aluminum chloride

2,5-dichlorobenzoyl chloride

→

crystals

收率 94.2%

2,5-Dichloro-2',5'-dimethylbenzophenone

收率 94.2%

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   萃取The aqueous layer was extracted with ether
3. 3
   萃取with ethereal extract
4. 4
   洗涤washed with water, saturated sodium bicarbonate, brine
5. 5
   干燥respectively, and then dried with magnesium sulfate
6. 6
   其他After the removal of solvent
7. 7
   其他the residue was recrystallized from methanol twice

实验过程

To p-xylene (120 ml, 0.98 mol) was added aluminum chloride (32 g, 0.24 mol) at room temperature. To this mixture 2,5-dichlorobenzoyl chloride (30 g, 0.14 mol) was added slowly. The reaction was exothermic and hydrogen chloride evolved from the reddish solution. After the addition, the mixture was stirred for 10 min and then hydrolysed by slow addition of water. The aqueous layer was extracted with ether. The organic layer was combined with ethereal extract and washed with water, saturated sodium bicarbonate, brine, respectively, and then dried with magnesium sulfate. After the removal of solvent, the residue was recrystallized from methanol twice and then from hexane to give 36.8 g (92%) crystals (mp 58-61° C.).

来源