反应 #1687652

反应方程式

o-toluoyl chloride

1,4-dichlorobenzene

Aluminum chloride

→

white crystals

收率 36.0%

2,5-Dichloro-2'-methylbenzophenone

收率 36.0%

溶剂

Ether

反应条件

后处理

1. 1
   温度The mixture was heated to 170° C. in 30 min
2. 2
   温度The resulting brownish solution was cooled to about 80° C.
3. 3
   workup.ADDITIONpoured onto ice
4. 4
   其他The organic layer was separated
5. 5
   workup.DISTILLATIONdistilled under vacuum
6. 6
   其他after the removal of ether
7. 7
   workup.DISTILLATIONThe residue from distillation
8. 8
   其他was recrystallized twice from hexane

实验过程

A mixture of o-toluoyl chloride (22 g, 0.17 mol) and 1,4-dichlorobenzene (120 g, 0.82 mol) was heated to 100° C. in a flask. Aluminum chloride (60 g, 0.45 mol) was added in one portion. The mixture was heated to 170° C. in 30 min and stirred at this temperature for 3 hours. The resulting brownish solution was cooled to about 80° C. and poured onto ice. Ether (50 ml) was added. The organic layer was separated and distilled under vacuum after the removal of ether. The residue from distillation was recrystallized twice from hexane to give 16 g of white crystals (36%).

来源