反应 #1687650

反应方程式

morpholine

piperidine

hydrogen chloride

2,5-dichlorobenzoylchloride

anisole

diphenyl ether

→

2,5-dichlorobenzoylpiperidine

2,5-dichlorobenzoylmorpholine

溶剂

toluene

pyridine

toluene

benzene

toluene

反应条件

后处理

1. 1
   其他at 0-5° C.
2. 2
   其他The solid products obtained
3. 3
   其他upon quenching with water
4. 4
   其他are purified by recrystallization from toluene/hexanes
5. 5
   洗涤After washing away the pyridinium salt
6. 6
   其他any excess amine, the product is crystallized from the toluene solution

实验过程

A wide variety of 2,5-dichlorobenzoyl-containing compounds (e.g. 2,5-dichlorobenzophenones and 2,5-dichlorobenzamides) can be readily prepared from 2,5-dichlorobenzoylchloride. Pure 2,5-dichlorobenzoylchloride is obtained by vacuum distillation of the mixture obtained from the reaction of commercially available 2,5-dichlorobenzoic acid with a slight excess of thionyl chloride in refluxing toluene. 2,5-dichlorobenzophenones (e.g. 2,5-dichlorobenzophenone, 2,5-dichloro-4'-methylbenzophenone, 2,5-dichloro-4'-methoxybenzophenone, and 2,5-dichloro-4'-phenoxybenzophenone) are prepared by the Friedel-Crafts benzoylations of an excess of benzene or substituted benzenes (e.g. toluene, anisole, or diphenyl ether, respectively) with 2,5-dichlorobenzoylchloride at 0-5° C. using 2-3 mole equivalents of aluminum chloride as a catalyst. The solid products obtained upon quenching with water are purified by recrystallization from toluene/hexanes. 2,5-dichlorobenzoylmorpholine and 2,5-dichlorobenzoylpiperidine are prepared from the reaction of 2,5-dichloro-benzoylchloride and either morpholine or piperidine, respectively, in toluene with pyridine added to trap the hydrogen chloride that is evolved. After washing away the pyridinium salt and any excess amine, the product is crystallized from the toluene solution.

来源