反应 #1687625

反应方程式

65

3-Mercapto-5(3-pyridyl)-1,2,4-triazole

potassium hydroxide

methyl iodide

→

3-Methylthio-5-(3-pyridyl)-1,2,4-triazole

溶剂

water

ether

反应条件

后处理

1. 1
   其他The ether phase was separated
2. 2
   萃取the aqueous phase extracted with 3×100 ml of ether
3. 3
   干燥The combined organic phases were dried over magnesium sulphate
4. 4
   其他Removal of the solvent in vacuo
5. 5
   其他gave a colorless solid, 66

实验过程

A solution of 20 g (0.100 mol) of 65 and 7.5 g (0.150 mol) of potassium hydroxide in 100 ml of water was mixed with a solution of 10 ml (0.160 mol) of methyl iodide in 100 ml of ether. After addition of 1 g of tetrabutylammonium hydrogen sulphate the mixture was stirred overnight at room temperature. The ether phase was separated and the aqueous phase extracted with 3×100 ml of ether. The combined organic phases were dried over magnesium sulphate. Removal of the solvent in vacuo gave a colorless solid, 66. Yield: 17.0 g (0.089 mol, 89%).

来源