反应 #168697

反应方程式

EtOAc

5-(3-bromo-phenyl)-5-methyl-morpholin-3-one

Lawesson's reagent

→

title compound

5-(3-Bromo-phenyl)-5-methyl-morpholine-3-thione

溶剂

THF

反应条件

后处理

1. 1
   温度The mixture was refluxed for 2 h

实验过程

A solution of 5-(3-bromo-phenyl)-5-methyl-morpholin-3-one (18 g, 67 mmol) in dry THF was treated with Lawesson's reagent (27 g, 67 mmol) in one portion at room temperature. The mixture was refluxed for 2 h. The title compound was obtained by chromatography on silica gel (PE/EtOAc=30:1 to 10:1). 1H-NMR (400 MHz, DMSO-d6): 11.08 (s, 1H), 7.50 (m, 2H), 7.35 (m, 2H), 4.36 (s, 2H), 4.00 (m, 1H), 3.73 (m, 1H), 1.51 (s, 3H).

来源