反应 #168501

反应方程式

4-[4-(2 {t-butoxycarbonylamino}ethyloxy)phenyl]butyl amine

butylamidino-3,5-diamino-6-chloropyrazinecarboxamide

→

4-[4-(2-aminoethyloxy)phenyl)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

反应条件

实验过程

Using general procedure Z, 4-[4-(2 {t-butoxycarbonylamino}ethyloxy)phenyl]butyl amine was converted into 4-[4-(2-{t-butoxycarbonylamino}ethyloxy)phenyl)]butylamidino-3,5-diamino-6-chloropyrazinecarboxamide, m.p. 118° C., APCI MS M/Z=521[C23H33ClN8O4+H]+, which was hydrolyzed and acidified with HCL to give 4-[4-(2-aminoethyloxy)phenyl)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, m.p.>178° C. (dec), M/Z=421 [C18H25ClN8O2].

来源