反应 #1683

反应方程式

trifluoroacetic acid

Boc-D-Phe-Pro-OBn

anisole

→

white powder

收率 85.0%

D-Phe-Pro-OBn.TFA

收率 85.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他the solvents were evaporated in vacuo
2. 2
   workup.DISSOLUTIONthe thick oily residue was dissolved in diethyl ether (1.5 L)
3. 3
   其他(72 hours)
4. 4
   过滤The white precipitate was filtered
5. 5
   洗涤washed with diethyl ether (300 mL)
6. 6
   其他dried

实验过程

To a stirring solution of Boc-D-Phe-Pro-OBn (68 g, 150 mmol) in dichloromethane (50 mL) at 0° C., was added anisole (20 mL) followed by trifluoroacetic acid (400 mL). After stirring for 3 hours, the solvents were evaporated in vacuo and the thick oily residue was dissolved in diethyl ether (1.5 L) and refrigerated (72 hours). The white precipitate was filtered, washed with diethyl ether (300 mL) and dried to yield 59.4 g (85%) of white powder.

来源