反应 #168093

反应方程式

Chloropyrazine

triethylamine

1-Isopropylpiperazine

→

4-Isopropyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl

溶剂

acetone

反应条件

后处理

1. 1
   其他The reaction mixture was evaporated
2. 2
   其他the residue was purified on a silicagel column with dichloromethane/MeOH (9:1) as eluent

实验过程

Chloropyrazine (2.3 g, 20 mmol) and triethylamine (3 g, 30 mmol) were mixed in acetone (8 mL) in a 20 mL microwave vessel. 1-Isopropylpiperazine (2.8 g, 22 mmol) was added and the reaction mixture was heated for 3300 seconds at 120° C. in a microwave oven. The reaction mixture was evaporated and the residue was purified on a silicagel column with dichloromethane/MeOH (9:1) as eluent. Yield: 1.64 g solid 4-isopropyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl.

来源