反应 #167935

反应方程式

racemic (cis)-tert-butyl 4-methoxy-3-methylpiperidine-1-carboxylate

TFA

→

racemic (cis)-4-methoxy-3-methylpiperidine 2,2,2-trifluoroacetate

溶剂

DCM

反应条件

后处理

1. 1
   浓缩The reaction mixture was then concentrated

实验过程

A solution of racemic (cis)-tert-butyl 4-methoxy-3-methylpiperidine-1-carboxylate (230 mg, 1.0 mmol) in DCM (2 mL) with TFA (0.23 mL, 3.01 mmol) was stirred at room temperature overnight. The reaction mixture was then concentrated to give racemic (cis)-4-methoxy-3-methylpiperidine 2,2,2-trifluoroacetate. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.27 (s, 3 H), 3.01-3.09 (m, 1 H), 2.93-3.00 (m, 1 H), 2.81-2.93 (m, 1 H), 2.69-2.77 (m, 1 H), 1.90-2.08 (m, 2 H), 1.57-1.67 (m, 1 H), 0.90 (d, J=7.1 Hz, 3 H).

来源