反应 #1677982

反应方程式

2-ethoxy-5-bromopyridine

ethylmagnesium bromide

4-propylphenylacetylene

→

1-(4-propylphenyl)-2-(2-ethoxy-pyridine-5-yl)-acetylene

溶剂

ether

ether

反应条件

后处理

1. 1
   workup.STIRRINGAfter stirring for 6 hours at room temperature

实验过程

0.05 m of ethylmagnesium bromide in ether are added to a mixture of 0.05 m of 4-propylphenylacetylene at 0°-10°. The mixture is stirred for 4 hours at room temperature and then a solution of 0.05 m of 2-ethoxy-5-bromopyridine and 0.5 g of NiCl2 (Ph3P)2 in ether is added. After stirring for 6 hours at room temperature and customary work-up 1-(4-propylphenyl)-2-(2-ethoxy-pyridine-5-yl)-acetylene is obtained.

来源