反应 #167209

反应方程式

1-pyridin-3-yl-imidazolidin-2-one

2-bromo-5-fluoro-3-methyl-benzo[b]thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

收率 61.6%

1-(5-Fluoro-3-methyl-benzo[b]thiophen-2-yl)-3-pyridin-3-yl-imidazolidin-2-one

收率 61.6%

溶剂

1,4-dioxane

反应条件

后处理

1. 1
   其他to afford the crude product
2. 2
   其他Purification by column chromatography on silica gel (1% MeOH in chloroform)

实验过程

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-imidazolidin-2-one (I-1b: 73 mg, 0.45 mmol) was reacted with 2-bromo-5-fluoro-3-methyl-benzo[b]thiophene (110 mg, 0.45 mmol), 1,4-dioxane (5 mL), copper iodide (8 mg, 0.045 mmol), trans-1,2-diamino cyclohexane (7 mg, 0.0675 mmol) and potassium carbonate (124 mg, 0.9 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform), afforded 90 mg of the product (61.64% yield).

来源