反应 #1671719

反应方程式

N-(2-Aminoethyl)-(2-nitroimidazol-1-yl)acetamide

2-oxo-1,4-dithiane

→

N-{2-[(2-mercaptoethylthio)acetylamino]ethyl}-(2-nitroimidazol-1-yl)acetamide

收率 37.5%

溶剂

methanol

acetone

反应条件

后处理

1. 1
   workup.WAITThe mixture was left at room temperature
2. 2
   其他The bulk of the solvent was removed
3. 3
   其他the resulting material purified by reverse phase h.p.l.c

实验过程

N-(2-Aminoethyl)-(2-nitroimidazol-1-yl)acetamide (40 mg, 0.23 mmol) in methanol (0.5 cm3) was added to 2-oxo-1,4-dithiane (40 mg, 0.27 mmol) in acetone (0.2 cm3) under an atmosphere of dry nitrogen. The mixture was left at room temperature and monitored by n.m.r. spectroscopy until the reaction was complete. The bulk of the solvent was removed, and the resulting material purified by reverse phase h.p.l.c. using aqueous methanol as the eluant. The pure N-{2-[(2-mercaptoethylthio)acetylamino]ethyl}-(2-nitroimidazol-1-yl)acetamide (30 mg) was isolated as a pale yellow solid.

来源