反应 #1665766

反应方程式

diketene

hydrofluoric acid

tetrahydronaphthalene

dodecyl-benzene

→

acetoacetyl-tetrahydronaphthalene

收率 86.0%

acetoacetyl-dodecyl-benzene

收率 40.0%

反应条件

后处理

1. 1
   workup.ADDITIONwere dropped in
2. 2
   workup.STIRRINGthe reaction mixture was stirred into 3 1 of icewater
3. 3
   萃取After extraction with methylene chloride
4. 4
   其他to remove the acid
5. 5
   workup.DISTILLATIONfrom the organic phase and distillation of the methylene chloride, distillation of the reaction

实验过程

100.8 g (1.2 mols) of diketene were added dropwise at -30°C to 0.5 1 of anhydrous hydrofluoric acid and a mixture of 0.6 mol of tetrahydronaphthalene and 0.6 mol of commercial grade dodecyl-benzene were dropped in. After stirring for 12 hours at room temperature, the reaction mixture was stirred into 3 1 of icewater. After extraction with methylene chloride, wahing with water to remove the acid from the organic phase and distillation of the methylene chloride, distillation of the reaction yielded 86 % of acetoacetyl-tetrahydronaphthalene boiling at 135°C under 0.5 torr and 77 g 40% of acetoacetyl-dodecyl-benzene boiling at 160°C under 0.5 torr as found by gas chromatographic determination of the fractions.

来源