反应 #166175

反应方程式

sodium tert-butoxide

phosphine

4-chlorotoluene

morpholine

→

4-Tolylmorpholine

溶剂

acetonitrile

CH2Cl2

dioxane

反应条件

后处理

1. 1
   其他In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar
2. 2
   其他The vial was sealed with a crimp top
3. 3
   其他the vial was removed from the heating block
4. 4
   温度cooled to room temperature
5. 5
   其他reaction
6. 6
   过滤filtering into a round-bottom flask
7. 7
   洗涤The vial was rinsed with CH2Cl2 (5 mL)
8. 8
   洗涤by washing of the filter cake with CH2Cl2 (2 mL)
9. 9
   其他The volatiles were removed on a rotary evaporator
10. 10
    浓缩the crude concentrate
11. 11
    其他was purified by silica gel column chromatography (25 g silica gel, 85:15 heptane:ethyl acetate)
12. 12
    其他The purified product was isolated as a beige solid

实验过程

In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with sodium tert-butoxide (56.9 mg, 0.592 mmol, 1.5 equivalents), tris(dibenzylideneacetone)dipalladium(0) (Pd2dba3) (3.62 mg, 0.00395 mmol, 0.01 equivalents), phosphine ligand (0.00869 mmol, 0.022 equivalents) and dioxane (0.79 mL). To the slurry was added 4-chlorotoluene (47 μL, 0.395 mmol, 1 equivalents) and morpholine (42 μL, 0.474 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 100° C. After 14 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. To assay the crude reaction, an aliquot (7 μL) was taken and diluted in acetonitrile (1.5 mL), then injected onto an HPLC instrument. For isolation purposes, the reaction solution was worked up by diluting with CH2Cl2 (2 mL) and filtering into a round-bottom flask. The vial was rinsed with CH2Cl2 (5 mL), followed by washing of the filter cake with CH2Cl2 (2 mL). The volatiles were removed on a rotary evaporator and the crude concentrate was purified by silica gel column chromatography (25 g silica gel, 85:15 heptane:ethyl acetate). The purified product was isolated as a beige solid. 1H NMR (400 MHz, CDCl3) δ ppm 7.10 (d, J=8.2 Hz, 1H), 6.88-6.81 (m, 2H), 3.87 (dd, J=5.7, 3.9 Hz, 4H), 3.15-3.09 (m, 4H), 2.29 (s, 3H).

来源