反应 #165778

反应方程式

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

desired product

收率 69.1%

3-amino-6-bromo-N-(phenylcarbonyloxy)pyrazine-2-carboximidamide

收率 69.1%

溶剂

dichloromethane

反应条件

后处理

1. 1
   浓缩concentrated in vacuo
2. 2
   其他The resultant residue was triturated with methanol

实验过程

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (890 mg, 3.836 mmol) was suspended in dichloromethane (11.56 mL) and treated with triethylamine (427.0 mg, 588.2 μL, 4.220 mmol) followed by benzoyl chloride (593.2 mg, 489.8 μL, 4.220 mmol) The reaction mixture was allowed to stir for 1 hour and concentrated in vacuo. The resultant residue was triturated with methanol to give the desired product as a pale beige solid (891 mg, 69% Yield). 1H NMR (400.0 MHz, DMSO) d 7.55 (2H, m), 7.65 (1H, m), 7.90 (2H, br s), 8.28 (2H, m), 8.33 (1H, s); MS (ES+) 337.87

来源