反应 #165751

反应方程式

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

收率 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

收率 70.0%

溶剂

DCM

反应条件

后处理

1. 1
   workup.ADDITIONwere added
2. 2
   其他the solvent was removed in vacuo
3. 3
   其他the residue triturated with MeOH
4. 4
   过滤The resultant filtrate was filtered off

实验过程

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

来源