反应 #164522

反应方程式

thiophenol

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

Compound 1

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

Para Toluenesulfonic Acid

→

8-phenethyl-2-phenylsulphanylmethyl-1,4-dioxa-8 azaspiro[4,5]decane

溶剂

toluene

反应条件

后处理

1. 1
   温度The reaction was refluxed for 13 hrs
2. 2
   温度at reflux temperature
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   其他to get the light brown solid product with a melting point of 58° C

实验过程

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane (Compound 1, 50 gm, 0.18 mole) and Para Toluenesulfonic Acid (PTSA, 2 gm) were dissolved in toluene (350 ml) at room temperature. 20 gm of thiophenol was added drop wise to the above solution. The reaction was refluxed for 13 hrs at reflux temperature. The solvent was distilled off to get the light brown solid product with a melting point of 58° C. The yield of the product was 95%.

来源