反应 #1637

反应方程式

(S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

benzyl bromide

sodium carbonate

→

title compound

(S)-N-Benzyl-1(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

溶剂

dimethylformamide

反应条件

后处理

1. 1
   过滤The mixture was filtered
2. 2
   洗涤the residue was washed with ethyl acetate
3. 3
   洗涤washed with water and brine
4. 4
   其他dried
5. 5
   其他evaporated
6. 6
   其他Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane)

实验过程

A solution of (S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol (1.9 g, 4.8 mMol) and benzyl bromide (0.57 ml, 4.8 mMol) in dimethylformamide (10 ml) containing sodium carbonate (770 mg, 7.2 mMol) was stirred at room temperature for 18 hours. The mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined, washed with water and brine, dried and evaporated. Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane) gave the title compound.

来源