反应 #163263

反应方程式

5-amino-2-trifluoromethylpyridine

chloropyrazine

→

title compound

Pyrazin-2-yl-(6-trifluoromethyl-pyridin-3-yl)-amine

溶剂

toluene

反应条件

后处理

1. 1
   温度cooled to room temperature
2. 2
   浓缩concentrated in vacuo
3. 3
   其他Purification by silica gel chromatography (40% EtOAc in hexanes)

实验过程

To a solution of 5-amino-2-trifluoromethylpyridine (0.81 g) in 3 Ml toluene was added chloropyrazine (0.45 Ml, 1.0 equiv) via syringe. The homogeneous solution was heated to 95° C., then cooled to room temperature and concentrated in vacuo. Purification by silica gel chromatography (40% EtOAc in hexanes) afforded the title compound: 1H NMR (400 MHz, CHLOROFORM-D) δ ppm 7.5 (s, 1H) 7.6 (s, 1H) 8.0 (s, 1H) 8.2 (s, 1H) 8.4 (s, 2H) 8.8 (s, 1H); (M+H)+241.1.

来源