反应 #161416

反应方程式

potassium carbonate

5-(benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline

phenylacetaldehyde

oxone

→

title compound

收率 42.0%

5-(benzoxazol-2-yl)-2-benzyl-1-(tetrahydropyran-4-yl)benzimidazole

收率 42.0%

溶剂

dimethylformamide

反应条件

后处理

1. 1
   过滤this was filtered
2. 2
   洗涤washed with water
3. 3
   其他The crystals obtained
4. 4
   其他were purified by silica gel column chromatography

实验过程

To a solution of 5-(benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline (see Working Example 20-2) (200 mg, 0.646 mmol) in dimethylformamide (3 mL) was added phenylacetaldehyde (101 mg, 0.840 mmol) and oxone (258 mg, 0.420 mmol), and this was stirred at room temperature for 3 hours. After the reaction was complete, aqueous potassium carbonate solution was added, this was filtered and washed with water. The crystals obtained were purified by silica gel column chromatography to yield the title compound (110 mg, 42% yield) as light brown amorphous mass.

来源