反应 #1614

反应方程式

2-benzyloxyphenol

potassium carbonate

(S)-Glycidyl-3-nitrobenzenesulphonate

→

title compound

(S)-Glycidyl-2-benzyloxyphenol

溶剂

acetone

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度under reflux for 15 mins
3. 3
   温度the reaction mixture was heated
4. 4
   温度under reflux for 23 hours
5. 5
   温度After cooling
6. 6
   过滤the reaction mixture was filtered
7. 7
   其他the solvent was evaporated
8. 8
   其他The residue was partitioned between ethyl acetate and water
9. 9
   洗涤washed with water and brine
10. 10
    其他dried
11. 11
    其他evaporated

实验过程

A mixture of 2-benzyloxyphenol (900 mg, 4.5 mMol) and potassium carbonate (1.87 g, 13.5 mMol) in acetone (45 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (1.0 g, 4.5 mMol) was added and the reaction mixture was heated under reflux for 23 hours. After cooling, the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.

来源