反应 #1605775

反应方程式

water

HCl

2-(5-methylpyridin-2-yl)acetonitrile

Borane tetrahydrofuran

→

2-(5-methylpyridin-2-yl)ethanamine

收率 41.0%

溶剂

THF

反应条件

后处理

1. 1
   温度The reaction was cooled to room temperature
2. 2
   温度the reaction mixture was then heated at 70° C. for 2 hrs
3. 3
   温度After cooling
4. 4
   洗涤the resulting solution was washed with ether
5. 5
   其他was basified with aq. NaOH (10 N) at 0° C. and saturated with K2CO3
6. 6
   萃取then extracted with ether (5×100 mL)
7. 7
   干燥The organic layer was dried over MgSO4
8. 8
   过滤filtered
9. 9
   其他evaporated

实验过程

To a solution of 18 g of crude 2-(5-methylpyridin-2-yl)acetonitrile in dry THF (100 mL) was added dropwise Borane-tetrahydrofuran complex (1.0 M in THF, 232 mL, 232.5 mmol, 4 eq) at 0° C. under N2 atmosphere. The reaction mixture was then heated to 60° C. overnight. The reaction was cooled to room temperature, aq.HCl (6 N, 40 mL) was added carefully and the reaction mixture was then heated at 70° C. for 2 hrs. After cooling, water was added and the resulting solution was washed with ether. The aqueous layer was basified with aq. NaOH (10 N) at 0° C. and saturated with K2CO3 then extracted with ether (5×100 mL). The organic layer was dried over MgSO4, filtered and evaporated to give 7.6 g of crude 2-(5-methylpyridin-2-yl)ethanamine. (96% crude yield)

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