反应 #1605772

反应方程式

NH3

2-methoxy-4-methylbenzoic acid

EDC

HOBt

→

2-methoxy-4-methylbenzamide

收率 83.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   洗涤then washed successively with HCl (1N)
2. 2
   干燥NaHCO3, water and brine, dried over MgSO4
3. 3
   过滤filtered
4. 4
   其他evaporated
5. 5
   其他The residue was recrystallized from ethyl acetate/hexane

实验过程

To a mixture of 2-methoxy-4-methylbenzoic acid (20 g, 120.4 mmol), EDC (23.1 g, 120.4 mmol) and HOBt (16.3 g, 120.4 mmol) in dichloromethane (1 L) was added NH3 (7N in MeOH, 52 mL, 3 eq) dropwise. The reaction mixture was stirred at room temperature overnight then washed successively with HCl (1N), saturated aq.NaHCO3, water and brine, dried over MgSO4, filtered and evaporated. The residue was recrystallized from ethyl acetate/hexane to give 16.5 gr of 2-methoxy-4-methylbenzamide (83% yield).

来源