反应 #1605763

ord-a50ed6faaed94d19b66f1e8ea92859ff

反应方程式

Cc1cc(C(=O)O)oc1C
4,5-dimethyl-furan-2-carboxylic acid
COC(=O)[C@H](N)CC(C)C
D-leucine methyl ester
COC(=O)[C@@H](CC(C)C)NC(=O)c1cc(C)c(C)o1
(R)-methyl 2-(2,3-dimethylfuran-5-carboxamido)-4-methylpentanoate
收率 27.0%

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Prepared in a similar manner to example 4 using 4,5-dimethyl-furan-2-carboxylic acid and D-leucine methyl ester. Yield: 27%. 1H NMR (500 MHz, CDCl3): ÿ 0.96 (t, 6H), 1.66 (m, 3H), 1.96 (s, 3H), 2.26 (s, 3H), 3.75 (s, 3H), 4.78 (m, 1H), 6.51 (d, 1H), 6.89 (s, 1H). MS (M+H, 268).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09072313B2uspto-grants-2015_07