反应 #160511

反应方程式

hydrochloric acid

5-benzyloxy-2-bromo-4-methylbenzaldehyde

N-(benzyloxycarbonyl)-alpha-phosphonoglycine trimethyl ester

1,1,3,3-tetramethylguanidine

→

title compound

收率 58.1%

(Z)-3-(5-Benzyloxy-2-bromo-4-methylphenyl)-2-benzyloxycarbonylaminoacrylic acid methyl ester

收率 58.1%

溶剂

dichloromethane

反应条件

后处理

1. 1
   过滤the precipitated solid was collected by filtration
2. 2
   洗涤washed with water
3. 3
   其他dried under reduced pressure

实验过程

To a solution of 5-benzyloxy-2-bromo-4-methylbenzaldehyde (0.39 g) and N-(benzyloxycarbonyl)-alpha-phosphonoglycine trimethyl ester (0.38 g) in dichloromethane (2 mL) was added 1,1,3,3-tetramethylguanidine (0.18 g) at room temperature and this mixture was stirred at room temperature for 2 days. To this reaction mixture was added 1 mol/L hydrochloric acid and the precipitated solid was collected by filtration, and washed with water, dried under reduced pressure to give the title compound (0.34 g).

来源