反应 #1597038

反应方程式

2-ethyl-1-butanol

triethylenediamine

p-toluenesulfonyl chloride

→

title compound

收率 95.6%

Toluene-4-sulfonic acid 2-ethylbutyl ester

收率 95.6%

溶剂

DCM

DCM

反应条件

后处理

1. 1
   萃取extracted with 1.0N NaOH (2×40 mL)
2. 2
   其他The organic layer was collected
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   过滤filtered
5. 5
   其他isolated by rotary evaporation

实验过程

To a solution of 2-ethyl-1-butanol (1.00 g, 9.79 mmol), triethylenediamine (1.32 g, 11.7 mmol) in DCM (30 mL, 0.5 mol) cooled to 0° C. was added p-toluenesulfonyl chloride (1.96 g, 10.3 mmol) in DCM (10 mL) The reaction mixture was stirred for 30 min, and extracted with 1.0N NaOH (2×40 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and isolated by rotary evaporation to give the title compound (2.40 g).

来源