反应 #1597037

反应方程式

toluene-4-sulfonic acid 4,4-difluorocyclohexylmethyl ester

sodium azide

→

title compound

4-Azidomethyl-1,1-difluorocyclohexane

溶剂

dichloromethane

N,N-Dimethylformamide

反应条件

后处理

1. 1
   温度cooled to room temperature
2. 2
   洗涤The organic layer was washed with water (2×5 mL)
3. 3
   其他collected
4. 4
   干燥dried over anhydrous sodium sulfate
5. 5
   过滤filtered
6. 6
   浓缩concentrated

实验过程

To a solution of toluene-4-sulfonic acid 4,4-difluorocyclohexylmethyl ester (100 mg, 0.33 mmol)) in N,N-Dimethylformamide (0.5 mL) was added sodium azide (32 mg, 0.49 mmol). The reaction mixture was stirred at 90° C. for 90 min, cooled to room temperature and diluted with dichloromethane (5 mL). The organic layer was washed with water (2×5 mL), collected, dried over anhydrous sodium sulfate, filtered, and concentrated to provide the title compound which was used without further purification.

来源