反应 #1597035

反应方程式

7-oxa-bicyclo[4.1.0]heptane

sodium azide

→

title compound

收率 10.6%

2-Azidocyclohexanol

收率 10.6%

溶剂

acetone

water

反应条件

后处理

1. 1
   温度The reaction mixture was refluxed for 12 h
2. 2
   其他The acetone was removed in vacuo
3. 3
   萃取the product was extracted with ethyl acetate (5 mL)
4. 4
   其他The organic layer was collected
5. 5
   干燥dried over anhydrous sodium sulfate
6. 6
   过滤filtered
7. 7
   浓缩concentrated

实验过程

To a solution of 7-oxa-bicyclo[4.1.0]heptane (0.300 g, 3.06 mmol) in acetone (3 mL) was added sodium azide (0.504 g, 7.75 mmol) in water (3 mL). The reaction mixture was refluxed for 12 h. The acetone was removed in vacuo and the product was extracted with ethyl acetate (5 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and concentrated to provide the title compound (46 mg).

来源