反应 #1597026

反应方程式

methyl 3-[5-(dimethylaminomethylenamino)pyrimidin-2-yl]benzoate

sulfuric acid

→

3-(5-hydroxypyrimidin-2-yl)benzoic acid

溶剂

water

反应条件

后处理

1. 1
   温度For work-up, the reaction batch is cooled
2. 2
   其他the precipitate formed
3. 3
   过滤is filtered off
4. 4
   洗涤washed with water
5. 5
   其他dried at 50° C. in a vacuum
6. 6
   其他drying cabinet

实验过程

103.5 g of methyl 3-[5-(dimethylaminomethylenamino)pyrimidin-2-yl]benzoate (364.04 mmol) are suspended in 1300 ml of water in a 2 l single-necked flask, and 160 ml of conc. sulfuric acid (95-97%) (2.88 mol) are subsequently added, and the reaction batch is warmed at 130° C. (oil-bath temperature) for 4 h. For work-up, the reaction batch is cooled, and the precipitate formed is filtered off, washed with water and dried at 50° C. in a vacuum drying cabinet.

来源