反应 #1597011

ord-721241ba7c134febb34ef855b2ff8f67

反应方程式

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
O=[N+]([O-])c1ccc(CCBr)cc1
4-nitrophenethyl bromide
O=C(O)c1cc(NCCc2ccc([N+](=O)[O-])cc2)ccc1O
5-(4-nitrophenethyl)aminosalicylic acid
收率 90.3%

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他in Synthesis Example 1

实验过程

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-nitrophenethyl bromide (900 mg, 3.92 mmole), 890 mg (50% yield) of 5-(4-nitrophenethyl)aminosalicylic acid was obtained as a pale yellow solid.: mp 234-236° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08211878B2uspto-grants-2012_07