反应 #1597004

ord-56dc57cadedb44788aa45984c17404d6

反应方程式

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
O=[N+]([O-])c1ccc(CBr)cc1
4-nitrobenzyl bromide
O=C(O)c1cc(NCc2ccc([N+](=O)[O-])cc2)ccc1O
5-(4-nitrobenzyl)aminosalicylic acid
收率 79.0%

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他in Synthesis Example 1

实验过程

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (2.00 g, 13.0 mmole) and 4-nitrobenzyl bromide (3.38 g, 15.6 mmole), 2.90 g (79% yield) of 5-(4-nitrobenzyl)aminosalicylic acid was obtained as a pale yellow solid.: mp 211-212° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08211878B2uspto-grants-2012_07