反应 #1597000

ord-24de5626b9994731955aae6708df4b27

反应方程式

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
Fc1c(F)c(F)c(CBr)c(F)c1F
pentafluorobenzyl bromide
O=C(O)c1cc(NCc2c(F)c(F)c(F)c(F)c2F)ccc1O
5-(pentafluorobenzyl)aminosalicylic acid
收率 60.0%

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他in Synthesis Example 1

实验过程

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and pentafluorobenzyl bromide (1.02 g, 3.92 mmole), 650 mg (60% yield) of 5-(pentafluorobenzyl)aminosalicylic acid was obtained as a white solid.:mp>190° C. (decompose).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08211877B2uspto-grants-2012_07