反应 #1596999

ord-1efe9fdd3f6846eb8bbff2f0e670935f

反应方程式

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
COc1ccc(CCl)cc1
4-methoxybenzyl chloride
COc1ccc(CNc2ccc(O)c(C(=O)O)c2)cc1
5-(4-methoxybenzyl)aminosalicylic acid
收率 50.0%

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他in Synthesis Example 1

实验过程

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (1.00 g, 6.53 mmole) and 4-methoxybenzyl chloride (1.23 g, 7.84 mmole), 890 mg (50% yield) of 5-(4-methoxybenzyl)aminosalicylic acid was obtained as a white solid.:mp 205-206° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08211877B2uspto-grants-2012_07