反应 #1596996

ord-128b3b4e09954149a920b362c22a9eb1

反应方程式

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
ClCc1ccc(Cl)cc1
4-chlorobenzyl chloride
O=C(O)c1cc(NCc2ccc(Cl)cc2)ccc1O
5-(4-chlorobenzyl)aminosalicylic acid
收率 53.0%

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他in Synthesis Example 1

实验过程

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-chlorobenzyl chloride (630 mg, 3.91 mmole), 480 mg (53% yield) of 5-(4-chlorobenzyl)aminosalicylic acid was obtained as a white solid.:mp 227-228° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08211877B2uspto-grants-2012_07